Operational research – “HIV, HPV and associated cancers”

Operational research – “HIV, HPV and associated cancers”

This call for proposals aims to support operational research projects to test innovative strategies to improve access to, and the quality and efficiency of early diagnostic, prevention and treatment services of Human papillomavirus (HPV)-related cancers in people living with HIV (PLHIV).

The linkages between HIV, the human papillomavirus and associated cancers are now well established: people who are immunocompromised are more likely to have a persistent HPV infection, which may progress more quickly to precancerous lesions or cancer. Cancers associated with HPV are preventable diseases. They are also curable if detected early and treated effectively. However, in low-income countries, access to preventive measures is limited and cancers caused by HPV are often not identified until they have reached an advanced stage. This has a significant impact on the survival rate of patients, as access to treatment at an advanced stage of the disease (e.g. cancer surgery, radiotherapy and chemotherapy) is also very limited in these contexts.

Against this backdrop, Projects will aim in particular to:

• Ensure the widespread integration of HPV screening and early management of precancerous lesions in sexual and reproductive health consultations, as well as in routine follow-up for PLHIV.
• Ensure the widespread introduction of diagnostic tests based on the most promising new technologies (molecular tests, other new tests and self-sampling devices, point of care).
• Assess the feasibility of different management methods for all cancers associated with HPV (laser, thermal ablation, cryotherapy, etc.) in a decentralized context.
• Promote the HPV vaccination among adolescents and young adults, and particularly among key populations (MSM, sex workers).